HIV-Associated Nephropathy in an HIV-2-Infected Patient
World Journal of AIDS (WJA)
- 2 million
people are thought to be infected. HIV-associated nephropathy (HIVAN) occurs in
about 7% of patients with HIV-1 infection and is one of the most important causes
of end-stage renal disease in this population. The only reported case of HIVAN related
to HIV-2 infection was described by Izzedine et al. (2006). Aim: The aim of this paper is to report a case of HIVAN
in an HIV-2-infected patient, a rarely described condition. Case presentation: We
describe a case of a 40-year-old HIV-2-infected female from Angola hospitalized
following a six-month history of fever, fatigue, anorexia and weight loss. Laboratory
data revealed anaemia, leukopenia and renal dysfunction with nephrotic range proteinuria.
Renal biopsy was performed, revealing findings consistent with HIVAN. Also, a presumed
diagnosis of ganglionic tuberculosis was established. Conclusion: The slow progression
of HIV-2 disease could explain the low frequency of this condition, however, more
studies should be carried out for a better understanding of HIV-2 pathophysiology
and its associated complications.